Open AccessMethylenetetrahydrofolate Reductase Genotypes and Early-Onset Coronary Artery Disease
Author(s) -
Aviv Mager,
Shadan Lalezari,
Tamar Shohat,
Yochai Birnbaum,
Yehuda Adler,
Nurit Magal,
Mordechai Shohat
Publication year - 1999
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.100.24.2406
Subject(s) - methylenetetrahydrofolate reductase , medicine , hyperhomocysteinemia , odds ratio , coronary artery disease , gastroenterology , homocysteine , case control study , myocardial infarction , risk factor , genotype , age of onset , endocrinology , disease , genetics , biology , gene
Homozygosity for the common (677C-->T) mutation in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with hyperhomocysteinemia, but there is uncertainty as to the association between this mutation and coronary artery disease (CAD). This study examined the association between MTHFR genotypes and age at onset of CAD.
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