Open AccessDownregulation of the Na + -Creatine Cotransporter in Failing Human Myocardium and in Experimental Heart Failure
Author(s) -
Stefan Neubauer,
Helga Remkes,
Matthias Spindler,
Michael Horn,
Frank Wiesmann,
Jürgen Prestle,
Bernd Walzel,
Georg Ertl,
Gerd Hasenfuß,
Theo Wallimann
Publication year - 1999
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.100.18.1847
Subject(s) - creatine , phosphocreatine , medicine , heart failure , endocrinology , creatine kinase , cardiology , energy metabolism
The failing myocardium is characterized by depletion of phosphocreatine and of total creatine content. We hypothesized that this is due to loss of creatine transporter protein.
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