Open AccessChlamydia pneumoniae Infection of Vascular Smooth Muscle and Endothelial Cells Activates NF-κB and Induces Tissue Factor and PAI-1 Expression
Author(s) -
Ralf Dechend,
Matthias Maass,
Jens Gieffers,
Rainer Dietz,
Claus Scheidereit,
Achim Leutz,
Dietrich C. Gulba
Publication year - 1999
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.100.13.1369
Subject(s) - chlamydophila pneumoniae , tissue factor , medicine , proinflammatory cytokine , thrombogenicity , vascular smooth muscle , endothelium , plasminogen activator inhibitor 1 , tissue factor pathway inhibitor , interleukin 8 , downregulation and upregulation , immunology , cytokine , plasminogen activator , inflammation , chlamydia , biology , smooth muscle , chlamydiaceae , platelet , biochemistry , gene , coagulation
Recent reports link C. pneumoniae infection of arteriosclerotic lesions to the precipitation of acute coronary syndromes, which also feature tissue factor and plasminogen activator inhibitor 1 (PAI-1) overexpression. We investigated whether or not C. pneumoniae can induce thrombogenicity by upregulation of procoagulant proteins.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom