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Infusion of large volumes of fluid into normal dogs produces a progressive rise in venous pressure with an initial parallel rise in cardiac output succeeded by a fall. On the basis of these experiments and other considerations which are discussed, it is concluded that the cardinal hemodynamic defect common to all types of heart failure is a disproportion between inflow load and cardiac output. The various general circulatory disorders are classified as primary disorders of filling and primary disorders of emptying with various subgroups.

Experimental Hypervolemic Heart Failure: Its Bearing on Certain General Principles of Heart Failure