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Reduced sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA2a isoform) activity is a major determinant of reduced contractility in heart failure. Ca2+-ATPase inactivation can occur through SERCA2a nitration. We therefore investigated the role of SERCA2a nitration in heart failure.

Increased Nitration of Sarcoplasmic Reticulum Ca 2+ -ATPase in Human Heart Failure

Increased Nitration of Sarcoplasmic Reticulum Ca ²⁺ -ATPase in Human Heart Failure