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Although increased activity of angiotensin-converting enzyme (ACE) has been associated with increased cardiac collagen, no studies to date have established a direct cause-and-effect relation between the two.

circulation

Increased Myocardial Collagen Content in Transgenic Rats Overexpressing Cardiac Angiotensin-Converting Enzyme Is Related to Enhanced Breakdown of <i>N</i> -Acetyl-Ser-Asp-Lys-Pro and Increased Phosphorylation of Smad2/3

Increased Myocardial Collagen Content in Transgenic Rats Overexpressing Cardiac Angiotensin-Converting Enzyme Is Related to Enhanced Breakdown of N -Acetyl-Ser-Asp-Lys-Pro and Increased Phosphorylation of Smad2/3