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To the Editor:In their interesting study, Sorensen et al1 demonstrated in young women that contraceptive depot medroxyprogesterone acetate (MPA)-induced hypoestrogenism may impair endothelium-dependent arterial function as measured by cardiovascular magnetic resonance. According to Hashimoto et al,2 endothelium-dependent vasodilation varies during the menstrual cycle, and endogenous estradiol may be involved in this menstrual cycle-related vascular function. In addition, endothelium-dependent vasodilation decreased in women with low plasma concentrations of estrogen, whereas estrogen replacement improved endothelial function by increasing expression of endothelial nitric oxide synthase. Thus, endothelium-dependent vasodilation may be regulated in part by ovarian hormones such as estrogen.Our …

circulation

Long-Term Use of Contraceptive Depot Medroxyprogesterone Acetate in Young Women Impairs Arterial Endothelial Function Assessed by Cardiovascular Magnetic Resonance