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To the Editor:Catecholamine-induced polymorphic ventricular tachycardia (CPVT) is characterized by episodes of syncope, seizures, or sudden death in response to physical activity or emotional stress. The two modes of inheritance that have been described are autosomal dominant1 and autosomal recessive.2 Mutations in the ryanodine receptor 2 gene ( RYR2 ), which encodes a cardiac sarcoplasmic reticulum Ca2+ release channel, were shown to cause the autosomal dominant form of the disease.3Recently, Priori et al …

RYR2 and CASQ2 Mutations in Patients Suffering From Catecholaminergic Polymorphic Ventricular Tachycardia