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The pacemaker current I(f) contributes to spontaneous diastolic depolarization of cardiac autonomic cells. In heterologous expression, HCN channels exhibit a hyperpolarization-activated inward current similar to I(f). However, the links between HCN genes and native I(f) are largely inferential, and it remains unknown whether I(f) is essential for cardiac pacing.

circulation

Dominant-Negative Suppression of HCN Channels Markedly Reduces the Native Pacemaker Current <i>I</i> <sub>f</sub> and Undermines Spontaneous Beating of Neonatal Cardiomyocytes

Dominant-Negative Suppression of HCN Channels Markedly Reduces the Native Pacemaker Current I f and Undermines Spontaneous Beating of Neonatal Cardiomyocytes

Dominant-Negative Suppression of HCN Channels Markedly Reduces the Native Pacemaker Current I _f and Undermines Spontaneous Beating of Neonatal Cardiomyocytes