English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

To the Editor:A recent issue of Circulation contained an interesting study by van’t Hooft et al1 reporting a novel functional polymorphism (a T to C substitution at position −265) in the promoter region of the apolipoprotein A-II (apoA-II) gene. ApoA-II is the second quantitatively major protein component of HDL. In the above-mentioned study, the −265C allele was associated with decreased plasma apoA-II concentration, enhanced postprandial metabolism of large VLDL, and decreased waist circumference in healthy 50-year-old men.1Important and rather surprising advances in our understanding of the role of apoA-II have been reported recently and have mainly been produced by analyses of genetically modified mice.2 In line with the findings of van’t Hooft et al,1 these advances revealed a consistent relationship of apoA-II with non-esterified fatty acids (NEFA) and …

On the Mechanisms by Which Human Apolipoprotein A-II Gene Variability Relates to Hypertriglyceridemia