Open AccessEffects of Angiotensin II on Cardiac Function and Peripheral Vascular Structure During Compensated Heart Failure in the Rat
Author(s) -
Sylvia Heeneman,
Jos F.M. Smits,
Peter Leenders,
Paul Schiffers,
Mat J.A.P. Daemen
Publication year - 1997
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/01.atv.17.10.1985
Subject(s) - medicine , angiotensin ii , endocrinology , vascular resistance , peripheral , heart failure , cardiac output , cardiac function curve , atrial natriuretic peptide , cardiac index , renin–angiotensin system , blood pressure , saline , nitric oxide synthase , nitric oxide
The present experiments were designed to test the hypothesis that the activation of the renin-angiotensin system during compensated heart failure may have adverse effects on cardiac function and change the peripheral vascular structure. ANG II (250 ng/kg/min) or saline (0.9% NaCl) were infused in myocardial-infarcted and sham-operated rats. After 2 weeks, cardiac function and peripheral vascular changes were investigated.
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