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Excess iron may increase oxidative stress and play a role in vascular inflammation and atherosclerosis. Here we determined whether the iron chelator, desferrioxamine (DFO), ameliorates oxidative stress and cellular adhesion molecule expression in a murine model of local inflammation.

Iron Chelation Inhibits NF-κB–Mediated Adhesion Molecule Expression by Inhibiting p22 phox Protein Expression and NADPH Oxidase Activity

Iron Chelation Inhibits NF-κB–Mediated Adhesion Molecule Expression by Inhibiting p22 ^phox Protein Expression and NADPH Oxidase Activity