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Atherosclerosis is associated with immune responses to oxidized low-density lipoprotein (oxLDL). The presence of activated macrophages and T cells in lesions suggests that cell-mediated immune reactions are taking place during the disease process. However, the role of specific immune responses has remained unclear. We have previously shown that transfer of CD4+ T cells from apolipoprotein E knockout mice (apoE(-/-)) into immunodeficient apoE(-/-) scid/scid mice accelerates disease.

Adoptive Transfer of CD4+T Cells Reactive to Modified Low-Density Lipoprotein Aggravates Atherosclerosis

Adoptive Transfer of CD4⁺T Cells Reactive to Modified Low-Density Lipoprotein Aggravates Atherosclerosis