Open AccessEplerenone With Valsartan Effectively Reduces Atherosclerotic Lesion by Attenuation of Oxidative Stress and Inflammation
Author(s) -
Jun Suzuki,
Masaru Iwai,
Masaki Mogi,
Akira Oshita,
Toyofumi Yoshii,
Jitsuo Higaki,
Masatsugu Horiuchi
Publication year - 2006
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/01.atv.0000204635.75748.0f
Subject(s) - eplerenone , valsartan , oxidative stress , inflammation , medicine , lesion , cardiology , pathology , aldosterone , spironolactone , blood pressure
Angiotensin II contributes to atherogenesis, mainly through oxidative stress and inflammation. Recent data suggest that aldosterone is implicated in some effects of angiotensin II. We hypothesized that aldosterone could directly contribute to oxidative stress and atherosclerotic lesion formation.
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