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Sphingosine 1-phosphate (S1P) is a bioactive phospholipid acting both as a ligand for the G protein-coupled receptors S1P1-5 and as a second messenger. Because S1P1 knockout is lethal in the transgenic mouse, an alternative approach to study the function of S1P1 in endothelial cells is needed.

Stable Knock-Down of the Sphingosine 1-Phosphate Receptor S1P 1 Influences Multiple Functions of Human Endothelial Cells

Stable Knock-Down of the Sphingosine 1-Phosphate Receptor S1P ₁ Influences Multiple Functions of Human Endothelial Cells