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Jean Vague from the University of Marseille was the first to foresee the importance of regional adipose tissue distribution when he suggested that a “male” pattern of body fat distribution, which he referred to as android obesity, was the form of obesity more likely to be accompanied by diabetes, hypertension, and heart disease, as opposed to the typical, rather benign, “female” pattern of body fatness, which he described as gynoid obesity.1 In the early 80’s, the late Per Bjorntorp from the University of Gothenburg in Sweden had come across Vague’s literature, and he took advantage of the availability of anthropometric variables such as waist and hip circumferences to develop a simple index of body fat distribution, the waist to hip ratio (WHR).2–5 Having access to two prospective studies of middle-aged men and women, the Swedish team found that the proportion of abdominal fat (as crudely appreciated by the WHR) was an independent risk factor for the development of cardiovascular disease and diabetes over a follow-up period of more than a decade.2,3 Simultaneously, in the United States, Ahmed Kissebah and his group6 also generated results emphasizing the importance of regional adipose tissue distribution as an important correlate of metabolic complications that had been, in the past, associated with excess weight per se. These results published in the early 80’s have generated great interest from the scientific and medical community, and over the last 20 years a flourishing and abundant literature has been published on the topic. As for many groups around the world, the publication of Bjorntorp’s early results raised our interest, and we initially focused our …

Energy Partitioning in Gluteal-Femoral Fat: Does the Metabolic Fate of Triglycerides Affect Coronary Heart Disease Risk?