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Estrogen replacement therapy (ERT) ameliorates symptoms in postmenopausal women with syndrome X. We hypothesized that estrogen deprivation and replacement may modulate coronary expressions of angiogenic molecules, thereby modifying the coronary capillary network in perimenopausal women.

In Vivo Estrogen Manipulations on Coronary Capillary Network and Angiogenic Molecule Expression in Middle-Aged Female Rats