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The industrial scale production viability of commercial and therapeutical biotechnological products, such as drugs, is significantly dependent of the separation and purification techniques applied. The use of two-aqueous phase systems (ATPS) is proposed as an alternative to purification, because allows the separation and analysis of biological particles, so that these do not lose their activities or desired properties. This technique is interesting for large scale purification because it allows selective partition with high yield potential and good cost-benefit relation. The present work intends to study the purification of clavulanic acid (CA) by liquid-liquid extraction in ATPS applying a new aqueous polymeric system composed of two polymers, namely polyethylene-glicol (PEG) and polyacrylate (PAA). Different aqueous polymeric system (PEG/PAA) compositions are being utilized, employing different molar masses and concentrations of PEG and 8000g/mol molar mass of PAA. At light of the information obtained the best extraction point for clavulanic acid, in the presence of Na2SO4 was defined at MPEG=400 g/mol, CPEG=17,5% (m/m) and CNaPA=22,5% (m/m) with K= 19,14, ηT=91,21%, BM=101,69 e R=0,45. While in the presence of NaCl, the best result found was at: MPEG=400 g/mol, CPEG=35% (m/m) e CNaPA=10% (m/m) with K=11,96 ηT=80,04%, BM=90,18

Utilização de sistemas poliméricos de duas fases aquosas (SPDFA) compostos por polietileno glicol/ácido poliacrílico (PEG/APA) para extração de ácido clavulânico