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MAZZUCHELLI-DE-SOUZA, J. Structural modelling and in silico analysis of E6 protein of the Deltapapillomavirus genus. 2018. (178 f.). Ph. D. these (Biothecnology) – Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, 2018. Papillomaviruses (PVs) are widely studied viruses, emphasizing their ability to infect the epithelial and mucosal tissues in several animals, including humans, causing benign lesions that may occasionally result in cancer. Among the genera that infect animals, Deltapapillomaviruses have a veterinary, ecological and historical importance because they are capable of infecting their natural host and other animals. Therefore, this work contemplates all viral types belonging to the Delta-PVs, including their history. Among the proteins translated by the PVs, three of them are considered oncogenic proteins: E5, E6 and E7. Determining the structure of a protein is crucial to the elucidation of its function, allowing applications in the areas of protein engineering, genomic annotation and rational design of drugs. The three-dimensional structure of the E6 protein of each viral type belonging to the genus Deltapapillomavirus was determined by molecular modeling by homology. The evolutionary history of these proteins was evaluated based on the generation of phylogenetic trees and their physicochemical properties were analyzed. In addition, due to its high degree of conservation, E6 has been shown to be useful as a molecular marker. Despite being considered rare, papillomas lesions were observed in sheep on a farm in the state of São Paulo. The molecular diagnosis of these lesions was performed. The results showed for the first time in the world that, despite being ovines, the causative agent of papillomatosis was a bovine papillomavirus, BPV2, a Delta-PV. Thus, in addition to discussing Delta-PVs, this thesis demonstrates in practice the ability of this genre to break the species-specific barrier.

Modelagem estrutural e análise<i> In silico </i>da proteína E6 do genêro <i>Deltapapillomavirus</i>.