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ARAKAWA, N.S. Microbial Transformations and cytotoxic evaluation of sesquiterpene lactones from Viguiera robusta Gardn. (Asteraceae). 2007. 141f. Thesis (Doctoral). Faculdade de Ciências Farmacêuticas de Ribeirão Preto – Universidade de São Paulo, Ribeirão Preto, 2007. The microbial transformation of secondary metabolites is an emerging technique in Brazil with high potential to obtain biotransformed compounds with new and different molecules which can show enhanced biological activities. Herein, microbial transformations of secondary metabolites from Viguiera robusta Gardn. (family Asteraceae), with emphasis in sesquiterpene lactones (STLs), were proposed with the aim to evaluate their cytotoxic activity against tumor cells lines. Isolation and purification of STLs were carried out through chromatographic methods and structural elucidation by spectroscopic methods. The evaluation of cytotoxic activity of the biotransformed metabolites was proposed due to the fact that previous studies indicated potential cytotoxic activity of the STLs budlein A against SK-BR-3 and JURKAT cells lines.

Transformações microbianas e avaliação da citotoxicidade de lactonas sesquiterpênicas de 'Viguiera robusta' Gardn. (Asteraceae)