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MARTINS, Tássia Joi. Evaluation of the theranostic effect by interaction between ruthenium phthalocyanine complexes and quantum dots nanoparticles. Photophysics, photochemical and photobiology studies. 2017. 207f. Tese (Doutorado) – Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, 2017. Cancer is one of the leading causes of death worldwide. Contemporary therapies do not bring the expected effectiveness and the treatment is often non-selective and its application is associated with several side effects, such as: the possibility of damage to genetic material or induction of secondary cancer process by radiotherapy; increasing resistance of tumor cells to chemotherapeutic agents, which translates into a high social and economic costs; significant reduction in the quality of life of patients underwent surgery and their long and expensive hospitalization. In contrast, antitumor photodynamic therapy (PDT) is a non-invasive method consisting of three components: a chemical compound called photosensitizer, light of a specific wavelength, and oxygen. This combination initiates a series of photochemical reactions leading to generation of reactive oxygen species and/or free radicals, which cause the death of cancer cells. Combining therapy and diagnostics has been the aim of many studies, improving the efficacy of the treatment. In this work, we propose the study of interaction between ruthenium phthalocyanines compounds and CdTe-MPA quantum dot, once in literature is described that quantum dots can transfer energy for phthalocyanines, increasing its citotoxycity. It was evaluated the cytotoxic effects of the species that produced singlet oxygen ( 1 O2) and its effects with different axial ligand in the sctrucuture of ruthenium phthalocyanines complexes. It was performed also photophysics and photochemical studies to evaluate the system for theranotic purposes. The results showed that the ruthenium phthalocyanines are good photosensitizer candidates once it presented high cytotoxity effects against different cancer cells lines after irradiation, even in low concentrations. Regarding to the interaction between phthalocyanines and quantum dots, it was demonstrated that the complexes could quenched the nanoparticles fluorescence occurring the static quenching mechanism.

Complexos rutênio-ftalocianinas como candidatos a fotossensibilizadores: estudos fotoquímicos, fotofísicos, fotobiológicos e avaliação do efeito \"teranóstico\" da interação com pontos quânticos