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Paula VJR. Effects of lithium on the expression of the enzymes activity phospholipase A2 and glycogen synthase kinase 3beta and its relationship with the phosphorylation state of tau protein [Thesis]. Sao Paulo: "Faculdade de Medicina, Universidade de Sao Paulo"; 2015. SUMMARY The present study compared the effect of lithium chronic treatment with subtherapeutic doses (0.02mM and 0.2mM) and therapeutic dose (2mM) in primary cortical and hippocampal neurons cell culture. This samples were analyzed and compared with the control group (no treatment). The study's goal was: 1) to evaluate in these Cell Culture a different activity kinases (PKA, CaMKII, AKT and GSK3β), different phosphorylation site of the Tau (199, 205, 214, 396, Cterminal and Six isoforms) and PLA2 inhibition; 2) To investigate how signaling pathways involved in modulation of tau phosphorylation from the inhibition of PLA2 in primary cultures of neurons; 3) analyze an expression of neurotrophic factors (BDNF) and cytokines (GM-CSF, IL-1b, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, IFNy TNFα 4) to evaluate gene expression via microarray with different doses of lithium

Efeitos do lítio sobre a expressão e atividade das enzimas fosfolipase A2 e glicogênio sintase quinase 3beta e sua relação com o estado de fosforilação da proteína tau