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A disfuncao de vias aereas em pacientes com Sindrome do Desconforto Respiratoria Agudo (SDRA) e caracterizada por limitacao do fluxo expiratorio e hiperinsuflacao dinâmica. As alteracoes morfologicas possivelmente associadas com tais alteracoes funcionais tem sido investigadas em modelos experimentais de lesao pulmonar aguda, que mostram necrose e descamacao epitelial em vias aereas distais. Entretanto, ate o momento, essa avaliacao nao foi realizada em humanos. O objetivo deste estudo foi investigar as alteracoes estruturais e inflamatorias nas pequenas vias aereas de pacientes com SDRA. Com este proposito, estudamos, retrospectivamente, o tecido pulmonar de 31 pacientes com SDRA (A: PaO2/FIO2 Airway dysfunction in patients with acute respiratory distress syndrome (ARDS) is evidenced by expiratory flow limitation and dynamic hyperinflation. The morphological alterations potentially associated with these functional changes have been investigated in experimental models of Acute Lung Injury, which show epithelial necrosis and denudation in distal airways. To date, however, no study has focused on the morphological airway changes in lungs from human subjects with ARDS. Objective: To evaluate structural and inflammatory changes in distal airways in ARDS patients. Methods and Results: We retrospectively studied autopsy lung tissue from 31 ARDS patients (A: PaO2/FIO2

Caracterização das alterações estruturais e de matriz extracelular de pequenas vias aéreas em pacientes com síndrome do desconforto respiratório agudo