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Casarano, R. Biodegradable Copolymers with Potential use as Biomaterials. 2009. 280p. PhD Thesis – Graduate Program in Chemistry. Instituto de Química, Universidade de São Paulo, São Paulo. With the goal of obtaining a new class of biodegradable copolyesters with improved properties isosorbide succinate (IS) moieties were incorporated into the poly(L-lactide), PLLA, backbone. Three miscible block copolymers and one miscible random copolymer with both hydrophobic character and final degradation temperature higher than PLLA and possessing low average molar masses were obtained through different approaches. Additional investigations involving the incorporation of IS or LLA residues into poly(3-hydroxybutyrate), PHB, backbone were performed. The incorporation of IS moieties into PHB main chain imparted similar results. Starting from one of the approaches, with improved synthesis conditions and using a chain extensor, miscible block copolymers with high average molar masses were obtained with different mer compositions of LLA and IS. Films obtained from the copolymer presented mechanical properties slightly greater than those from PLLA. Acid (pH = 2) and alkaline (pH = 12) hydrolytic degradation data for the copolymers and PLLA films were comparable. The copolymers are capable of forming fibers by melt spinning, needed for applications that aim at the production of biodegradable and bioresorbable sutures. Non-woven mashes, with potential use as cell growth scaffold and drug-controlled delivery devices, were successfully obtained from the copolymer solutions by electrospinning. The introduction of isosorbide succinate moieties into PLLA main backbone increased significantly the cell adhesion of the non-woven mashes attained from the copolymers.

Copolímeros biodegradáveis com potencial uso como biomateriais