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RUIZ, L.S. Fungemia by yeasts: molecular and phenotypic profiles and susceptibility to antifungal agents of samples isolated at Hospital das Clínicas de Botucatu, São Paulo, Brazil. 2008. 111f. Thesis (Microbiology) – Institute of Biomedical Science, University os São Paulo, SP Ciências Biomédicas, Universidade de São Paulo, São Paulo, 2008. This study, which involved 70 samples of Candida obtained from the blood of patients admitted at the Hospital das Clínicas of the city of Botucatu, state of São Paulo, Brazil, was aimed to: identify the isolates in a culture collection by the traditional method and by a commercial kit (API 20C); identify the presence of C. dubliniensis by phenotypic and genotypic (PCR) techniques; determine and compare the minimum inhibitory concentrations (MICs) of these samples in regard to ketoconazole, fluconazole, itraconazole, voriconazole, 5-fluorocytosine, amphotericin B and caspofungin (“E-test”), using RPMI 1640 + MOPS medium; molecularly characterize sequential samples from the same patient by the PFGE technique; study the genotypic profile of all the isolates of C. albicans and C. parapsilosis by means of the microsatellite technique and compare the results with those obtained by the PFGE technique. The level of agreement between the traditional method and the API 20C system was 93%. No isolate of C. dubliniensis was identified in the study. In relation to antifungal susceptibility, the strains of C. parapsilosis, C. albicans, C. tropicalis and C. glabrata presented a high percentage of samples susceptible to the seven drugs tested. The samples of C. guilliermondii, C. krusei and C. tropicalis presented a lower percentage of susceptibility in regard to, fluconazole, 5fluorocytosine and itraconazole. Most of the isolates were susceptible to amphotericin B. The molecular analysis by the PFGE technique revealed six different karyotype profiles among 24 sequential samples. In the comparison between the PFGE and microsatellite techniques, the latter showed a greater discriminatory power for C. albicans and C. parapsilosis.

Fungemia por leveduras: perfis fenotípicos e moleculares e sensibilidade antifúngica de amostras isoladas no hospital das clínicas de Botucatu, São Paulo.