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This in vitro study aimed to analyze the potential of restorative materials containing the antibacterial monomer 12-methacryloyloxydodecylpyridinium bromide (MDPB) for controlling the advance of bacterial induced secondary root caries-like lesions. Class V cavities (2 mm x2 mm) were prepared in seventy-five human root fragments. Specimens were randomly divided in 5 groups (n=15 fragments per group) and restored as follows: (I) MDPB-free adhesive system + MDPB-free composite (negative control); (II) resin modified glass ionomer (RM-GIC; positive control); (III) MDPB-free adhesive system + MDPB-containing composite (2.83% MDPB); (IV) MDPB-containing adhesive system + MDPB-free composite; (V) MDPB-containing adhesive system + MDPB-containing composite. Artificial secondary root caries lesions were produced by a biological artificial caries challenge. The restored specimens were immersed into a culture medium containing Streptococcus mutans and sucrose for 15 days. Histological slices (80 ± 20 μm) of the specimens were used for measuring the mean depths of the artificial lesions produced in both margins of the restorations using polarized light microscopy. Results were expressed in percentage related to the mean depth of the negative control, considered 100%. Data were compared by ANOVA followed by the Tukey’s test (p ≤ 0.05). The depths of lesions adjacent to cavities filled with RM-GIC (GII; 85.17 ± 15.2%) were significantly (p < 0.01) shallower than those adjacent to restorations with MDPB-free composite (GI; 100.00 ± 10.04%), despite the presence of MDPB in the adhesive system (GIV; 101.95 ± 21.32%). The depths of lesions adjacent to cavities restored with MDPBcontaining 3 composite (GIII; 82.68 ± 12.81%and GV; 85.65 ± 15.42%), despite the adhesive system used, were similar to those of RM-GIC (GII). Mean lesions depths in these groups decreased 13% (GV) to 17% (GIII) in relation to the negative control (GI). Concluding, MDPB-containing composite inhibits the progression of artificial secondary root caries lesions regardless of adhesive systems.

Análise in vitro do efeito inibitório de restaurações contendo o monômero antibacteriano MDPB na progressão de cáries secundárias em raizes dentárias