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A presenca da hipertensao arterial pode comprometer a qualidade da reparacao ossea, pois a doenca e caracterizada por alteracoes fisiopatologicas vasculares e do metabolismo mineral. Com o objetivo de avaliar a neoformacao e o remodelamento osseo, este trabalho investigou o processo da reparacao ossea em ratos geneticamente hipertensos (SHR) e de seus controles Wistar-Kyoto (WKY). Defeitos bicorticais de 2mm de diâmetro no lado direito e de 5mm no lado esquerdo, foram realizados com trefinas na regiao do ângulo de mandibula. Os animais, divididos em grupos de cinco individuos cada, foram sacrificados apos 2, 3, 5, 10, 15, 30, 60 e 90 dias pos-operatorios; as mandibulas foram removidas, fixadas em formol a 10%, descalcificadas em acido formico a 20%, incluidas em parafina e as seccoes histologicas, de 7μm de espessura, coradas com hematoxilina e eosina. As imagens foram capturadas com aumento de 40x e a area do defeito mensurada pelo programa de histometria digital Image J versao 1.4. A analise estatistica revelou que nao houve diferenca significante na comparacao entre as linhagens WKY e SHR (p =0,884), independente dos periodos ou lados avaliados; entre periodos, nas linhagens WKY (p = 0,101) e SHR (p = 0,479), independente dos lados avaliados; entre periodos por linhagens no lado direito; e entre linhagens por lados, esquerdo com p = 0,466 e direito com p = 0,689, independente do fator periodo. Houve diferenca estatisticamente significante entre o lado esquerdo e o direito (p Arterial hypertension may affect the quality of bone repair because this disease is characterized by physiopathological vascular and bone metabolism changes. With the objective of evaluating the bone neoformation and remodeling, this study investigated the process of bone repair in spontaneously hypertensive rats (SHR) and their match controls Wistar-Kyoto (WKY). Through-in-through defects were done with trephine burs in the mandibular angle area, of 2mm diameter on the right side and 5mm diameter on the left side. The animals were divided into groups of five individuals each one and killed after 2, 3, 5, 10, 15, 30, 60 and 90 post operative days; the mandibles were removed, fixed in 10% formalin solution, decalcified with 20% formic acid, and embedded in paraffin; the histological sections of 7μm thickness were stained with hematoxylin and eosin. The images were captured with 40x magnification and the defect area was measured by the image processing program Image J version 1.4. The statistical analysis showed that there is no significant difference in the comparison of WKY and SHR strains (p = 0,884), independent of periods or sides; among periods, in the WKY strain (p = 0,101) and SHR one (p = 0,479), independent of sides; among periods by strains on the rightside; and among strains by sides, left side with p = 0,466 and right side with p =0,689, independent of periods. There is a significant difference between left and rightside (p

Avaliação histológica da reparação óssea em defeitos bicorticais no ângulo de mandíbula de ratos geneticamente hipertensos e de seus controles Wistar-Kyoto