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de Paula, L. B. Effects of nanoemulsion-chloro-aluminum phthalocyanine in the regulation of epidermal growth factor pathway in glioblastoma and medulloblastoma. 2015. 111 pages. Thesis (Doctoral Degree) – Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil. Glioblastoma multiforme (GBM) can develop quickly without clinical, radiological or morphological of a less malignant precursor tumor. However, a new tumor can grow from normal glial cells or their precursors, is called the primary GBM. Medulloblastoma is also a malignant embryonic tumor of the cerebellum, whose incidence occurs preferentially in children under 7 years. Brain tumors differ from between them at the molecular level. The amplification of the EGFR gene (Growth Factor Receptor Epidermal) with an increase in the expression of EGF receptor (Epidermal Growth Factor) is the main cause in primary GBM compared to secondary GBM and is also present in medulloblastoma. This work to investigate the gene expression profile of the EGF pathway and the protein profile of tumor suppressor genes and oncogenes tumor cell lines of glioblastoma and medulloblastoma after treatment with photodynamic therapy (PDT). PDT's share knowledge in brain tumors at the molecular level allowed to discovery of genes that participate in the regulation of gene expression of other RTK/Ras/PI3-K and AKT/MAPK signaling pathways such as that are responsible for the increased cell proliferation, survival or resistance to apoptosis and loss of adhesion and migration, and may reveal a high degree of invasiveness. For this reason, treatment with photodynamic therapy in brain tumor cells adds relevant information about the process of cellular proliferation and cancer biology.

Efeitos da Nanoemulsão de Ftalocianina Cloro-Alumínio na Regulação da Via do Fator de Crescimento Epidermal em Glioblastoma e Meduloblastoma