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SANTIAGO, G. L. Bioactive phenolic compounds of native fruits from Myrtaceae family: Evaluation of bioaccessibility and functional potential related to cardiovascular diseases. Dissertação (Mestrado) – Faculdade de Ciências Farmacêuticas – Universidade de São Paulo, São Paulo, 2018. The cardiovascular diseases (CVD) are the leading cause of death worldwide. The risk of development of these disorders can be reduced, partially, by a vegetal-based diet. In this way, the Brazilian native fruits from Myrtaceae family may contribute to improve the diet quality, once they have high quantity of bioactive compounds, such as the phenolic (PC). The knowledge about the cardioprotective effects of consuming these fruit polyphenols is limited, so this study aimed to evaluate the bioaccessibility of the cambuci and jaboticaba PC and their in vitro potential on CVD-related mechanisms. First, gastrointestinal digestion simulation of each fruit pulp was done, and then the polyphenols rich extracts were obtained by solid phase extractions, before and after the pulps digestion. The polyphenols rich extracts had their phenolic concentrations determined and were used to evaluate the capacity of PC in inhibit the Angiotensin Converting Enzyme (ACE) activity and the platelet aggregation induced by ADP. The results were expressed as IC50, considering the total phenolic content per milliliter of reaction. According to the results, the in vitro digestion process was able to release the polyphenols from the food matrix. Therefore, the bioaccessibility had no significant effect on ACE activity, but decreased the IC50 values of platelet aggregation. In relation to the extracts from PA and C18 columns, the higher tannin concentration In comparison to the IC50 values presented by PA extracts, the higher concentrations of tannins in the last one were not enough to improve the antiaggregant effect, but were important to increase the inhibition of ACE activity. Cambuci polyphenols presented higher antihypertensive and antiaggregant potentials than the jaboticaba compounds. In this respect, the ingestion of cambuci and jaboticaba and the use of their purified polyphenols can be of particular importance in reducing the risk for the CVD development.

Compostos bioativos fenólicos de frutos nativos da famí­lia Myrtaceae: Avaliação da bioacessibilidade e do potencial funcional relacionado às doenças cardiovasculares

Compostos bioativos fenólicos de frutos nativos da famí­lia Myrtaceae: Avaliação da bioacessibilidade e do potencial funcional relacionado às doenças cardiovasculares

Compostos bioativos fenólicos de frutos nativos da família Myrtaceae: Avaliação da bioacessibilidade e do potencial funcional relacionado às doenças cardiovasculares