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The process intensification is important in the search for less harmful and safe equipment and reactions, an example is the application of microreactors. The pharmaceutical industry is the largest beneficiary of this technology because microreactors, devices with microchannels up to 100 μm, can reduce the time required to develop and produce a new drug in years and can be mounted in extremely small and compact industrial units. The increase in diabetes cases in Brazil in the last decade has been encouraging the search for new drugs. In this work, the application of capillary microreactors is studied in the synthesis of (Z)-5-(4hydroxy-3-methoxybenzylidene)2,4-thiazolidinedione (HMTZD) and (Z)-5-(3-hydroxy-4methoxybenzylidene)2,4-thiazolidinedione (MHTZD), obtained from the reaction of 2,4thiazolidinedione (TZD) with 4-hydroxy-3-methoxybenzaldehyde (Vanillin) and its isomer, 3hydroxy-4-methoxybenzaldehyde (Isovanillin), which can be used in the synthesis of molecules with biological activity. Maximum yields of 98% in 480 min, for the product HMTZD, and 73% in 120 min, for the product MHTZD, were obtained, contradicting literature that shows a reaction time for this synthesis of 20 h to 40 h. In the flow synthesis in the microreactor, it was evident that the higher the temperature the higher the conversion of TZD and the yield of the product, reaching 100%, in ethanol working with the temperature of 160°C. The production in the batch process and the microreactor were calculated and, when compared, showed that only two 1 mL microreactors in their best operating condition are able to produce three times more than a 60 mL batch reactor. By the study of kinetics, the reaction using ethanol does not favor the formation of reactions in parallel or in series. The qualitative analyzes showed that the expected products was formed and with a high degree of purity.

Otimização da síntese de intermediários de fármacos com reagentes naturais: Aplicação à reação da 2,4-tiazolidinadiona com vanilina e isovanilina