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Gastaldo, Brunno Carvalho, Action of constituents of Solidago chilensis Meyen (Brazilian arnica) in rats wound healing mechanisms. 2013. 117 f. dissertation (master's degree) Faculty of Pharmaceutical Sciences University of São Paulo, São Paulo. in 2013 Medicinal plants are used by 80% of the world population. Brazil due its vast climatically diversity possess a strong traditional medicine. Many vegetal species are used by the population as anti-inflammatory and wound healer. In this picture there is Solidago chilensis. Ersatz of the Arnica Montana, and present in the ANVISA`s plants of interest list (RENISUS), posses a lagged scientific investigation. To support the popular use and elucidate questions about its mechanism of action were developed tests demonstrating the healing action of this specie. Open wound and air pouch experiments are developed with rats to determinate the activities as a pro or anti-inflammatory. These tests include a cellular migration count and cytosine dosage. In vitro essay were performed to indicate the predominant cellular type response and the toxic dosage (indicated by DNA fragmentation and the cellular viability). All the experiments were executed with the lyophilized 70% hydroethanolic extract, and the fractions chloroform, ethyl acetate, and aqueous. An alongside chemical screening by THL and HPLC were carried on to determine by NMR some key compounds. It was verified a significant reduction of the wound in the 5th day in the open wound experiment, which is the passage of the inflammation phase to the granulation phase. Also it was noted ad increase of the L-selectin, IL-1, and IL-6 liberation by neutrophils but a decrease when administrated concomitant with a proinflammatory stimulus. Several compounds must be acting to culminate this activity, including endotoxin, inherent contaminants in the non-sterile environment, toxic diterpenes and flavonoids such as quercitrin. The aforementioned phenomenon points to a modulatory effect of the immune response. The obtained result indicates a potential use in wound healing processes with has immune deficiency and also hiperresponsivite. Further studies will be performed to verify the most active fraction, and its main compounds.

Ação de constituintes de Solidago chilensis Meyen (arnica brasileira) nos mecanismos de cicatrização de feridas em ratos