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TORRES, LHL. Effects of cigarette smoke in oxidative stress in the central nervous system of young mice. Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Brasil, 2009. Cigarette’s smoke is composed of more than 4.700 substances, many of them are toxic. The central nervous system (CNS) has few antioxidant defenses, is rich in easily oxidable lipids and contains high levels of transition metals which are involved in the formation of free radicals. There are evidences that tobacco smoke causes changes in the antioxidant enzymes in adult rodents, but little is known about its effects during CNS development. Thus, the aim of this work was to evaluate the possible effects of cigarette’s smoke in the CNS of young mice. BALB/c mice were exposed to a mixture of mainstream and sidestream smoke of cigarette (Souza Cruz – Red Derby) in a polypropylene chamber attached to a Venturi system. Besides acute exposure, performed at the 18th day of life, the animals were exposed from the 5th day of life for 13 or 35 days, 2 hours a day, 7 days in a week. The animals were then euthanized by cervical dislocation, immediately or three hours after the last exposure. The determinations of enzymatic activities of glutathione peroxidase, glutathione reductase, glutathione S-transferase, and the quantification of malonaldehyde (MDA) and 3-nitrotyrosine in cerebellum, frontal cortex, striatum, hippocampus and hypothalamus were performed. Our results indicate that the CNS in development is susceptible to cigarette’s smoke. Alterations in antioxidant enzymes in different brain structures were detected immediately after the last exposure suggesting differences in sensitivity of different

Efeitos da inalação da fumaça do cigarro no estresse oxidativo do sistema nervoso central de camundongos jovens