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The objective of this study was to assess the possible association between the polymorphism 260C/T of the gene CD14, Arg7S3Gln TLR2, Asp299Gli and Thr39911e TLR4 and -174G/C of the gene IL6 with myocardial infarction in young adults. For that a case control study was conducted and the case group was formed by 102 patients who had myocardial infarction, and the control group by 108 individuais without history of cardiovascular disease. The genotyping was performed by PCR-RFLP. There was no association between the distribution of genotypes of SNPs 260C/T of the gene CD14, Arg7S3Gln TLR2, Asp299Gli and Thr39911e TLR4 and -174G/C of the gene IL6 between the two groups studied (p<O.OS). The serum inflammatory blood profile was related with polymorphism 174G/C IL-6 in the group IAM. The GG genotype was linked with elevated PAI-1 concentrations (p<0.0001), the genotype GC with larger quantities of red blood cells (p=0.02) and CC genotype with high concentrations of fibrinogênio (p<0.01) and leucocytes increased quantity (p<O.OS). The CC genotype of polymorphism of -260C/T CD14 also showed associated with the elevation in PAI-1 concentrations (p<0.0001) and the CT genotype with elevated fibrinogênio concentrations (p<0.01). The GG genotype of the -174G/C IL-6 polymorphism was related with elevated glucose concentrations (p<O.OS) and CC genotype with decrease in the apoA (p <0.01) and HDL (p<0001) concentrations and elevation of the LDL (p <O.OS), total cholesterol (p <O.OS) concentrations. The CT genotype of -260C I T CD14 polymorphism also was Iinked with high total cholesterol concentrations (p <0.0001). In conclusion, the polymorphism is not associated with myocardial infarction in young patients, but the -260CT CD14 and -174 IL-6 SNPs appear to be related to the serum biochemicaJ, hematological and inflammatory blood profile in patients that had myocardial infarction.

Polimorfismo dos genes CD14, TLR2, TLR4, IL6 e sua associação com o infarto do miocárdio em adultos jovens