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The present work studies the solid partide size's influence of the rifampin and hydroxypropylmetylcellulose in kinetic release profile of the drug in matrix systems. The matrix tablets were formed by HPMC (A), isoniazid (B) and rifampin (C). The powders were dassified by sieving in four different particle size distribution. Particle size (t) Ao, Bo, Co A1, B1, A2, B2, C2 ~,B3, C3 C1 Sieve opening (mm) Not t;:::0,42 0,177 <t<0,250 t<0,150 homogenized Sieve number 40 80 100

Influência do tamanho de partículas sólidas de isoniazida, rifampicina e hidroxipropilmetilcelulose na liberação dos fármacos, a partir de sistemas matriciais