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Controlled release systems has been increasingly used into different purposes due to its applicability that turns it onto a technology able to supply economic and environmental needs, once thats allows using precise amounts of active ingredients and only on aimed locations. Among the variety of matrix options used in this systems, poly (vinyl alcohol) has been larged employed and can be obtained by thermal cycles technics. Azadirachtin, an active ingredient found in Neem seed oil has been described as a repellent of different kinds of insects and has great agriculture's applicability. Based on compound properties, was proposed to develop a controlled release system to combat flea Ctenocephalides felis felis. In the present study was performed physicochemical characterizations of matrix and devices through gel fraction, swelling tests, differential scanning calorimetry, scanning electron microscopy and biological characterizations by cytotoxicity assay of Neen's oil, matrix and devices and analysis of flea's behavior at neem's oil presence by bioassay. The physical-chemical characterizations has enabled to choose the most suitable matrix to device's development. The biological characterizations has been demonstrated absence of oil's cytotoxicity, matrices and devices and bioassay has resulted in 40% mortality of fleas. On kinetic's release, was cheked that all used encapsulating agents has allowed the release neem's oil active principles.

Desenvolvimento de um sistema de liberação controlada de princípios ativos do óleo de Azadirachta indica A. Juss em matriz de poli(álcool vinílico) (PVA) para aplicações em veterinária