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The aim of this work is to develop an automation sy stem for iodine-125 radioactive seed production by (Nd:YAG) laser weldi ng, which has been used successfully in Low Dose Rate (LDR) brachytherapy treatment. Thi s small seed consists of a welded titanium capsule, with 0.8mm in diameter and 4.5mm in length, containing iodine-125 adsorbed onto a silver rod. The iodine-125 seeds ar e implanted into the human prostate to irradiate the tumor for cancer treatment. Nowadays, the Radiation Technology Center, at IPEN-CNEN/SP imports and distributes 36,000 iodine125 seeds per year, for the clinics and hospitals in the country. However, the Brazilia n market potential is now over 8,000 iodine-125 seeds per month. The local production of these iodine-125 radioactive sources becomes a priority for the Institute, in order to r educe the price and the problems of prostate cancer management. It will permit to sprea d their use to a largest number of patients in Brazil. On the other hand, the industri al automation plays an important role for iodine-125 seeds in order to increase the productiv ity, with high quality and assurance, avoiding human factors, implementing and operating with Good Manufacturing Practices (GMP). The technology consists of appliance electro nic and electro-mechanical parts and components to control machines and processes. The a utom tion system technology for iodine-125 seed production developed in this work w as mainly assembled employing Programmable Logic Controller (PLC), stepper motors , d ivers, (Nd:YAG) laser welding machine, photoelectric sensors and supervisory. v SUMÁRIO Página 1 1.1 1.2 1.3

Automação do processo de soldagem a laser (Nd:YAG) para confecção das sementes de Iodo-125 utilizadas em braquiterapia