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ALMEIDA, M.V. Application pre-clinic of Synthetic phosphoethanolamine on epilepsies Experimental models.2007. 60 f. dissertacao (mestrado)Programa de Pos-graduacao de Interunidades em bioengenharia (EESC/FMRP/IQSC), Universidade de Sao Paulo, Sao Carlos. Phosphoethanolamine is one of mains the mammals membranes constituent and your organic deficiency is intensely related with Nervous System Central disturbances and epilepsies. Due to this evidences, it belongs to vanish importance knowledge the influence physicist-chemical properties, in the solid form and liquid form and your interrelations with possible effect anticonvulsive. The present work had for goals to evaluate biologically the possible effects anti convulsive and anti epilepticals of synthetical phosphoethanolamine SF and LF, front the convulsions induced for PTZ and in the epileptic state, detected in EEG, of epileptic Wistar mices. They were going used specific methodologies for both the study stages, incorporating models pre-clinical of anticonvulsivements medications neurological evaluations. The results pointed effect in the crises intensity decrease and of deaths front to the crises induction for PTZ, and effect anti convulsive of the liquid and solid form front the model of epileptic genetically mice, indicating Phosphoethanolamine probable has neurological action to the observed biological events. Keys-word: Farmakis. phosphoethanolamine. Epilepsies. Pre-clinical-administration.

Aplicação pré-clínica da fosfoetanolamina sintética sobre modelos experimentais de epilepsias