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LEGENDRE, D. F. (2003). Studies of Techniques Applied to Make a Textured and Biolized Surface Diaphragm, and Biological Performance In Vitro and In Vivo in a Membrane of a Ventricle Assist Device and Total Artificial Heart Fully Implantable. São Carlos, 2003. 103p. Dissertação (Mestrado) Escola de Engenharia de São Carlos, Universidade de São Paulo. It has been developed a high lifetime and biocompatible diaphragm to be used in a Left Ventricle Assist Device (LVAD) that is a reduced dimension totally implantable electromechanical device. It has been performed an endurance test on a textured diaphragm made of polyurethane. This test has evaluated the diaphragm resistance to be used in In Vivo tests with the LVAD implanted for fifteen days in calves. A natural endothelial cell surface has excellent thromboresistant characteristics. The quantity and the characteristics of the neointima formed into LVAD are determined by the material surface, hemodynamics of the blood through the device, and the physico-pathological conditions. The patch implantation into the abdominal aorta of pigs has isolated some normal variables that usually are present during LVAD utilization and that may interfere on the material biocompatibility. The evaluation of the material’s characteristics has been enhanced through its implantation at the descending aorta wall in contact with blood flow. Different kinds of contact surfaces of specific polyurethane are tested in seven In Vivo experiments. This study is totally focused in the reaction of the bloodmaterial interface. A histogical study is performed in the end of every animal experiment to analyze the interactions between blood and biomaterial. It’s emphasized the quantification and qualification of the neointima over the blood contact surface, calcification, and blood depositions.

Estudos de técnicas de texturização e biolização, e desempenho biológico in vitro e in vivo em membrana para um dispositivo de assistência ventricular e coração artificial totalmente implantáveis