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In this work, the synthesis of the trinuclear ruthenium complex [Ru3O(CH3COO)6(NO)(py)2]PF6 (py = pyridine) was performed following two different synthetic routes (conventional (a) and a new one (b)) in order to verify and to compare the efficiency of both. In addition, the mapping of the conventional synthetic route was done to analyze the best way to conduct it at each step for the synthesis to be successful. It was possible to state in route (a) that two precursors must be purified: precursor 1 [Ru3O(CH3COO)6(S)3] + and 3 [Ru3O(CH3COO)6(CO)(L)2], no purification of the final product being necessary. The modifications required for the optimization of synthesis (a) were the use of a freshly prepared solution of bromine and the substitution of the dry methanol in the washing flask by dry dichloromethane. We can not rule out the possibility of the new synthetic route (b), added to the modifications pointed out in this work, to present good results. The characterizations were made using UV-visible, infrared and NMR spectroscopy techniques. Reactivity studies for both complexes analyzed ([Ru3O(CH3COO)6(NO)(py)2]PF6 and [Ru III,III,III 3O(CH3COO)6(4-acpy)NO)]PF6), suggested the formation of the species [Ru3O(CH3COO)6(NO2 )(L)2] where L = 4-acpy or py this reaction being dependent on the concentration of hydroxyl ions in the medium. Studies of the reactivity and reduction of compound [Ru3O(CH3COO)6(NO)(py)2]PF6 with the biological reductant ascorbic acid, in the presence of OH ions, allowed to suggest a hypothesis for the NO release mechanism with redox stimulus, in the absence of light. It is proposed that the coordinated NO ligand undergoes a nucleophilic attack of the hydroxyl ions present in the medium, concomitant to an intra-molecular electron transfer that generates the species [Ru3O(CH3COO)6(NO2 )(py)2] . The latter is reduced by ascorbic acid, restoring the ligand NO which, now coordinated to the reduced metal unit [Ru3O], is finally labilized, generating the complex [Ru3O(CH3COO)6(S)(py)2] .

Estudo da reatividade de nitrosilos complexos trinucleares de rutênio em diferentes meios