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LIMA, J. P. C. Efeitos de um Estresse Social sobre a Atividade Imunologica Inata de Ratos “Intrusos”. [Effects of A Social Stress Over Innate Immune Response of “Intruders” Rats.] 2007. 130 f. (Dissertacao em Neurociencia e Comportamento). Instituto de Psicologia da Universidade de Sao Paulo, Sao Paulo, 2007. The present works shows the effects of social stress, produced by introducing a rat, in the condition of “intruder”, for one hour, in a community formed for three elements namely a dominant male , submissive male and a female, with preset social relations, concerning their behaviour, the biochemistry and the innate immune activity of neutrophils. The intruder animals displayed, in relationship to the control group, a tendency towards being more active and less anxious in the Open Field and the Plus Maze, as well as of serum corticosterone levels with higher values, as well as its oxidative burst being significantly increased. And, as in the frontal cortex as in hypothalamus is concerned, the author found significant activation of serotonergic systems. The data, had been indicative of the function of the reaction of stress in order to prepare the organism for a challenge: a activated HPA axis was increased, with favorable consequences for a fast action; an innate immune reply more effective and neurochemistry denoting cohibition of impulsive behaviours, allowing more adjusted choices in the context of social confrontation This reaction turned the organisms more active and efficient, in an example of the positive aspect of stress reaction. The data also demonstrated the existence and importance of the great individual differences and the need of keeping in mind the statistic approach and very careful interpretation of subtle stressors, whenever these differences appear clearly and may eventually induce to an interpretative error. Word-key: neuroimmunomodulation, social stress, neutrophils, 5HT, anxiety.

Efeitos de um estresse social sobre a atividade imune inata de ratos "intrusos"