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Melo S.R. Evaluation of the susceptibility of respiratory syncytial virus escape mutants to Palivizumab using “in vitro” microneutralization test. [Masters thesis (Microbiology)]. São Paulo: Instituto de Ciências Biomédicas, Universidade de São Paulo; 2017. Respiratory Syncytial Virus (HRSV) is a important pathogen for children. It is the major cause of acute respiratory infections and one of the main causes of hospitalizations and deaths in children under 5 years. Strains of HRSV with mutations in the binding site of Palivizumab have been showing resistance to the drug. Little is known about the prevalence of these mutations in clinical samples, despite their potential importance in viral pathology. In addition, there is almost no data on the molecular evolution of HRSV F protein, especially in Brazil. The aims of the present study is to characterize phenotypically by in vitro microneutralization assays, strains from children with no treatment with Palivizumab circulating in 2013 showing mutations in F protein, more specifically related to potential resistance in the binding epitopes of Palivizumab. As result of this study all samples tested were neutralized by Palivizumab, concluding that the mutations found did not confer resistance to the monoclonal.

Avaliação da susceptibilidade de mutantes de escape do vírus sincicial respiratório frente ao Palivizumab pelo método de microneutralização &lt;i&gt;in vitro&lt;/i&gt;.