English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

FERRARA JUNIOR, J. I. Effect of low-intensity laser treatment on experimental model of orofacial pain in masseter muscle of rats. 2017. 88 f. Masters thesis (Morfofunctional Sciences) Instituto de Ciências Biomédicas da Universidade de São Paulo, São Paulo, 2017. Temporomandibular disorder (TMD) is a collective term that encompasses a set of clinical problems that affect the masticatory muscles, the temporomandibular joint, and associated structures. It is the largest cause of non-dental pain in the orofacial region with 39.2% of the individuals presenting at least one TMD symptom of which 25.4% were associated with pain, and 15.4% presented muscle pain. Despite their high clinical prevalence, the mechanisms of chronic craniofacial muscle pain are not yet well understood. Experimental studies have been published indicating that inflammation plays a relevant role in the development of tissue disorders associated with these chronic dysfunctions, triggering the production of various chemical mediators by damaged tissue cells and newly infiltrated immune cells. Fractalkine is a chemokine that, under normal conditions, is expressed in abundance on the extracellular surface of neurons, and its receptor, CX3CR1, has been widely characterized in microglia. Studies have shown that fractalkine induces the activation and migration of microglia, suggesting that neurons can communicate with glial cells through the interaction of the fractalkine and the CX3CR1 receptor, promoting functional changes, including the release of cytotoxic and inflammatory mediators, collaborating for the maintenance of nociceptive processes. Treatments for TMD pain relief and control should be minimally invasive, reversible and conservative. Some drug therapies have undesirable effects. Because of this, other therapies are being investigated for pain relief, especially muscle pain, and low-intensity laser treatment (LILT) seems to be a promising option. Thus, the effect of LBI on the pain sensitivity of the animals in in vivo models of persistent pain through orofacial mechanical sensitivity evaluation and in vitro models of histological analysis of rat masseter and the evaluation of microglia activation as well the expression of fractalkine in immunohistochemical assays. The data obtained demonstrate that treatment with LBI reverses the mechanical hypersensitivity of the animals. This effect is due to an inhibition of the local inflammatory response, observed by the decrease of the inflammatory infiltrate visualized in the masseter after the LBI treatment and by a central inhibition of fractalkine observed in the trigeminal ganglion. Together, these data reinforce the role of LBI as an important therapeutic alternative, not only able to alleviate pain symptoms but which has systemic effects and modulates the inflammatory response at the central level.

Efeito do tratamento com laser de baixa intensidade em modelo experimental de dor orofacial no músculo masseter de ratos.