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ALMEIDA, F.P. Effects of thyroid hormone T3 in the central nervous system associated with diabetes mellitus induced by alloxan. 2016 69 p. Masters thesis (Physiology) ‐ Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, 2016. In recent years it has been shown that glucose metabolism disorders and disabilities and / or insulin resistance in the brain may be related to neurodegenerative diseases, suggesting that Diabetes Mellitus (DM) has a relationship with such diseases as Alzheimer's disease (AD). Moreover several studies suggest a modulation of thyroid hormones (TH) on insulin signaling and function of the nervous system, and that their lack or their excess are involved in neurological symptoms. However, little is known about the effects of TH function in the adult nervous system. The objective of this study was to analyze the relationship between hyperthyroidism and protein changes in the central nervous system associated with DM. For this, Wistar adult rats were injected with alloxan monohydrate (diabetic rats) or vehicle (euglycemic rats) and treated with T3 for 30 days. These animals were evaluated for motor activity, state of anxiety and cognitive memory performance in behavioral tests and the protein related signaling insulin, BDNF and markers of neurodegeneration, assessed by immunoblotting method, ELISA and PCR regions of the cortex and hippocampus. Chronic treatment with T3 produced an anxiolytic effect and a delay in the acquisition of learned information, although consolidation not be modified. Furthermore, T3 allowed improvement of the neurodegenerative process and the insulin signaling pathway in the hippocampus of diabetic animals. These data suggest, in general, a beneficial effect of TH on the the brain function of diabetic rats and suggests that depth investigations into the actions of THs in the adult brain can be of great relevance for future treatments for brain insulin resistance related to DM.

Efeitos do hormônio tireoideano T3 no sistema nervoso central associados a diabetes melito induzida por aloxana.