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Batagello DS. Distribution of neurons and terminal fields that express the Urocortin 3 in the Central Nervous Systems of Primate non-human (Cebus apella). [Masters Thesis]. São Paulo: Instituto de Ciências Biomédicas da Universidade de São Paulo, 2011. Urocortin 3 (UCN 3) is a neuropeptide with 38-aa and member of the corticotropinreleasing factor (CRF) peptide family, it is a selective agonist for the CRF2 receptor. Immunohistochemical and in situ hybridization performed in rodents showed containingneurons found in discrete regions of the central nervous system (CNS) such as the median preoptic nucleus, the rostral perifornical area and in the region between the fornix and the paraventricular nucleus of the hypothalamus at the mid level of it. The extrahypothalamic sites of UCN 3 mRNA expression are the medial nucleus of the amygdala and the superior paraolivary nucleus. The immunoreactive (UCN 3-ir) terminals are distributed to regions that mostly overlap the CRF2 mRNA expression. Therefore, these data suggest that UCN 3 would participate in the food intake and neuroendocrine controls. However, such mapping was not done in a nonhuman primate CNS model. In order to better understand such neuropeptide role in a mammalian model we proposed to study the UCN 3 distribution in the brain of a monkey. Cebus apella species (n=6), weighing 2200-2700 g. After the perfusion and cutting the brain and spinal cord in a freezing microtome, series of frontal sections (40 μm) were subjected to immunohistochemistry techniques; in situ hybridization, Nissl and Hematoxylin-eosin staining. The UCN 3 cells were found in the following regions: median preoptic nucleus, hypothalamic paraventricular nucleus, hypothalamic periventricular nucleus, juxtaparaventricular part of lateral hypothalamus, supra-optic nucleus, medial part of central amigdaloid nucleus, intralaminar nuclei of the thalamus and dentate gyrus of hippocampal formation. UCN 3-ir fibers and terminals were localized mainly in: medial preoptic area, hypothalamic paraventricular nucleus, ventromedial nucleus of the hypothalamus, lateral septum nucleus, and in the arcuate nucleus. We have found double-labeled cells (CRF/UCN 3) in the PaMD and, in β cells (UCN 3/insulin) of pancreas. Our results support that the sites that showed immunoreactive cells and/or which express the mRNA of UCN 3, and UCN 3 fibers in our experimental model of primate (Cebus apella) are located mainly in hypothalamic, amygdaloid and limbic sites and, there is colocalization between UCN 3/CRF cells in PaV and UCN 3/insulin β cells of pancreas. Key-words: Capuchin-monkey. Corticotropin-releasing factor. Neuropeptides. Hypothalamus .

Distribuição dos neurônios e campos terminais que expressam a urocortina 3 no sistema nervoso central de primata não-humano (Cebus apella).