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Turano HG. Alternative therapies for the treatment of infections produced by multidrug-resistant Pseudomonas aeruginosa strains endemic in Brazil. [dissertation (Microbiology)]. São Paulo: Instituto de Ciências Biomédicas, Universidade de São Paulo; 2012. Pseudomonas aeruginosa is a leading cause of nosocomial infections, which it has acquired an endemic status due to their intrinsic or acquired resistance to antibacterial agents commercially available. The aim of the study was to evaluate "in vitro" therapeutic options based on the synergistic activity. Ten clonally unrelated strains of P. aeruginosa, previously characterized as metallo-beta-lactamase (MβL) producers (i.e., SPM-1, VIM-1 and GIM-1) were evaluated. The synergistic effect was investigated by checkerboard” and Time-Kill assays. The combinations [Piperacillin/Tazobactam x Aztreonam] and [Tigecycline x bilayer fragments of dioctadecyldimethylammonium bromide (DDA)] showed synergistic activity for 90 and 100% of the strains, respectively. The results support the use of combined therapy by using [Piperacillin/Tazobactam x Aztreonam] against infections produced by strains of P. aeruginosa producing MβLs, moreover, [DDA / Tigecycline] may be the basis for build a new pharmaceutical form for clinical use.

Alternativas terapêuticas para o tratamento de infecções por Pseudomonas aeruginosa multirresistentes endêmicas no Brasil.