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Nascimento TL. Role of inducible Heat Shock Protein 70 (HSP70) in skeletal muscle atrophy and subsequent recovery [Master thesis (Morphofunctional Sciences)]. São Paulo: Instituto de Ciências Biomédicas, Universidade de São Paulo; 2012. Heat shock proteins play a key regulatory role in cellular defense. To investigate the role of the inducible 70-kDa heat shock protein (HSP70) in skeletal muscle atrophy and subsequent recovery, extensor digitorum longus (EDL) and Soleo (SOL) muscles from overexpressing HSP70 transgenic mice were immobilized during 7 days and subsequently released from immobilization and evaluated after 7 days. Histological analysis showed that there was a decrease in cross-sectional area of type I and II myofiber from SOL and type II myofiber from EDL muscles at 7-day immobilization in both wild type and HSP70 mice. At 7-day recovery, EDL and SOL myofibers from HSP70 mice recovered their size. The number of NCAM positive-satellite cells reduced after immobilization and recovery in EDL muscles from wild type mice, but it was unchanged in the muscles from HSP70 mice. Muscle tetanic contraction was unaltered in all groups from HSP70 mice. In addition, the increase of atrogin-1 and MuRF-1 gene expression was attenuated in HSP70 mice. Therefore, our study suggests that the HSP70 is important for structural and functional recovery of muscles after immobilization and this effect might be associated with preservation of satellite cell amount and regulation of key elements in muscle atrophy.

Papel da proteína de choque térmico 70 induzível (HSP70) na atrofia muscular e subsequente recuperação.