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RANGEL JR, M. J. R. Anatomic and functional mapping of the neural sites involved in the observed responses during the exposition of the environment of a social defeat. 2012. 53 p. Masters thesis (Morphofunctional Sciences) – Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, 2012. In the present work, we investigated the neural systems involved in the contextual defense to a social defeat. First, we established a protocol to observe contextual defensive responses in animals previously defeated by an aggressive conspecific. In this protocol, animals were kept ten days living in a apparatus composed by two cages (room and resident cages). On the 11 day animals were exposed to an aggressive conspecific and defeated in the resident cage. On the following day, animals were exposed to the apparatus, and contextual defensive responses were measured. These animals presented reliable defensive responses, characterized mostly by risk assessment behaviors. Next, we examined the pattern of Fos expression in the brains of these animals to determine the putative networks involved in the expression of contextual defensive responses to social defeat. Accordingly, increased Fos expression was found in posterodorsal part of the medial amygdalar nucleus (MEApd), rostral part of lateral septum (LSr), elements of the social responsive medial hypothalamic circuit (including, the medial preoptic nucleus, ventrolateral part of the ventromedial nucleus, tuberal part of the lateral hypothalamic area and ventral premammillary nucleus), the juxtadorsal part of the lateral hypothalamic area and the dorsomedial part of the dorsal premammillary nucleus (PDMdm). The data allowed us to outline a putative circuit involved in the expression of contextual defense to social defeat, and indicates that both innate and contextual defense to social threat apparently share the same neural circuits.

Mapeamento anátomo-funcional dos sítios neurais envolvidos nas respostas observadas durante exposição ao ambiente contextual de uma derrota social.