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CAMPOS-RODRIGUES, S. Functional and molecular evaluation of energy metabolism adaptations in liver from pregnant rats. 2011. 54 p. Masters thesis (Human Physiology) Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, 2011. The involvement of the liver in maternal glucose homeostasis is still unclear. This study evaluated the hepatic glucose production in pregnant rats and some of the hepatic metabolic pathways involved in metabolic disorders mediated by the liver in late pregnancy.There was a decrease in liver glycogen content and plasma glucose in pregnant rats. The rate of gluconeogenesis decreased as well as the contents of IR tyrosine phosphorylation after insulin stimulus, but the pSer-AKT, PEPCK, SHP2 contents, SHP2-IR association and the expression of PEPCK remained unaltered. The content of PTP1B and its association with IR decreases in the presence of insulin. The content of G6Pase, AMPK and the phosphorylation of AMPK α/1 and consequently the phosphorylation of ACC decreases in liver from pregnant animals. Triglyceride levels and the expression of FAS was increased in pregnant rats whereas the triglycerides reduced in the liver. The expression of G-6-Pase, MEs, LXR, SREBP1 and PFK decreased in the liver of pregnant rats. The results indicate no insulin resistance in the liver of pregnant rats, and that hepatic metabolic activity in this period is focused on de novo fatty acids synthesis.

Avaliação funcional e molecular de adaptações no metabolismo energético hepático ao final do período de prenhez em ratas.