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Frank KC. Malignant histological grading system: proposal for an adjusted grading system for oral squamous cell carcinoma [dissertation]. São Paulo: Universidade de São Paulo, Faculdade de Odontologia; 2019. Versão Original Squamous cell carcinoma represents 90% of malignant neoplasms in the oral cavity. Since it is a disease with high incidence and high risk, it is important to understand how it manifests both clinically and histologically for obtaining information to develop the best treatment and prognostic for patients. The international system used for classification is the clinical TNM staging system. However, this system does not guarantee a morphological and structural analysis of carcinoma. Thus, many researchers have given attention to this fact, making histological grading systems in order to assist in the treatment and in order to increase the quality of life and prognosis of patients with this neoplasia. The aim of the present study was to evaluate the histological grade of malignancy of 50 cases of oral squamous cell carcinoma located in tongue and buccal floor through histological grading systems of The World Health Organization (WHO), Brandwein-Gensler and Boxberg and relate their results to recent studies and to draw a new morphological gradading system. The 50 slides were stained with HE and analysed under optical microscope. Results: by WHO, 15 were well-differentiated, 26 moderately differentiated and 9 poorly differentiated. Boxberg with 18, 27 and 5 respectively and Brandwein-Gensler, with 22 low risk, 11 intermediated risk and 9 high risk. In relation to the findings of the study, we conclude that the different findings in the literature that are in discrepancy at all times and can be reduced if the combination of morphological parameters start being established in a new gradation that include several aspects of oral carcinomas.

Gradações histológicas de malignidade: proposição de novo método para análise em carcinoma epidermoide oral