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Frascino AVM. Aqueous ozone solution irrigations on bone monocortical wound healing in femurs of Wistar rats induced or not to diabetes: histomorphological and histomorphometric study [dissertation]. São Paulo: Universidade de São Paulo, Faculdade de Odontologia; 2011. Some accounts in the medical literature about ozone’s molecule properties to favorably interfere with tissue repair and its antimicrobial action have based the therapeutic usage of ozone to treat several diseases. No standardized investigation yet succeeded to establish the therapeutic effects over bone repair process of this triatomic molecule of the oxygen when diluted in pure water. In this investigation we evaluated the histomorphological aspects of bone tissue repair process after irrigation with 100 ml of the 4 ppm of the ozone dissolved in Milli-Q ® during drilling of the standardized monocortical wounds performed through trephine drill (2mm), after 7, 14 and 21 days in femurs of rats induced and not induced to diabetes by intraperitoneal injection of streptozotocin (STZ, Sigma). The wounds of the control groups were irrigated with 100ml of Milli-Q. The histomorphological evaluation revealed that the diabetic animals that received ozone showed intense hemorrhage, increased proliferation of blood vessels and immature bone trabeculae when compared with diabetic animals not submitted to the application of ozone in all evaluated periods. The non-diabetic animals that received ozone presented intense inflammatory infiltrate and increased proliferation of blood vessels compared to the control group. Comparatively wounds of the animals that received irrigation through ozonized water showed higher proliferation of blood vessels and bone trabeculae more immature when compared to groups that did not receive ozone. Histomorphometric of bone trabeculae development, comparatively in wounds of diabetic and non diabetic animals showed no statistically significant results (7 days, P=0,362; 14 days, P=0,54; 21 days, P=0,351) . The comparison of bone trabeculae development between wounds in the group of non-diabetic animals that received and did not receive ozone, 21 days postoperatively showed statistically significant (P = 0.034). These results suggests that the irrigation of bone wounds of animals induced and not induced to diabetes with 4 ppm of ozone diluted in Milli-Q were capable to stimulate the proliferation of blood vessels during the inflammatory phase of tissue repair without producing toxic or detrimental effects but did not improve bone trabeculae development when a diabetes state is present.

Efeitos do ozônio diluído em água no reparo de feridas monocorticais em fêmures de ratos induzidos ou não ao diabetes: estudo histomorfológico e histomorfométrico